Powder Texture Artemisinin has a Certain Solubility

Product Attribute

Powder Texture Artemisinin has a Certain Solubility

Application：

Health field:

Malaria treatment: Artemisinin is the first-line drug for the treatment of malaria. In clinical treatment, there are many drugs developed based on artemisinin, such as artemisinin tablets and artesunate injection. These drugs are administered orally or by injection, and play a key role in the treatment of malaria, especially chloroquine-resistant malaria.

Artemisinin is an important lead compound for the study of new antimalarial drugs. Scientists have developed a series of derivatives with higher antimalarial activity, better pharmacokinetic properties and lower toxicity by modifying the chemical structure of artemisinin, such as dihydroartemisinin and artemether, which are widely used in the prevention and treatment of malaria.

Powder Texture Artemisinin has a Certain Solubility

Product Information

Artemisinin is a sesquiterpene lactone compound containing a peroxy bridge structure, with a molecular formula of . Its chemical structure is unique. The peroxy bridge (-O - O -) in the molecule is the key structural part for its antimalarial activity. In addition, it also includes a lactone ring and multiple chiral centers. This complex structure gives it special chemical and biological activity.

Physical properties: Artemisinin is a colorless needle-shaped crystal with a melting point of 156-157℃ and a bitter taste. In terms of solubility, it is almost insoluble in water, has a certain solubility in organic solvents such as ethanol, ether, and petroleum ether, and has better solubility in chloroform.

Chemical properties: Due to the peroxy bridge structure, artemisinin is oxidizing. It can react with some reducing agents, and the peroxy bridge structure may break under certain conditions. In addition, the lactone ring can also undergo hydrolysis and other reactions under appropriate conditions. These chemical properties are of great significance for understanding the drug metabolism and mechanism of action of artemisinin.

Source and extraction method

Source: Artemisinin mainly comes from the plant Artemisia annua, which is an annual herb with fragrance. The stem is upright, with many branches on the upper part and longitudinal ridges. The leaves are alternate, and the leaves in the middle of the stem are pinnately divided twice, with small lobes linear or linear-lanceolate, entire or serrated. The head inflorescence is hemispherical or nearly hemispherical, and the flowers are yellow. Its leaves and flowers are the main parts for extracting artemisinin.

Extraction method:

Organic solvent extraction method: This is a commonly used extraction method. Artemisia annua is usually soaked and refluxed with organic solvents such as ether, petroleum ether, and ethanol. For example, after the dried leaves and flowers of Artemisia annua are crushed, they are soaked and stirred with ether to dissolve artemisinin in ether. After filtering, concentration and other operations, an extract containing artemisinin is obtained. It is further purified by column chromatography, recrystallization and other methods to obtain artemisinin with higher purity.

Supercritical fluid extraction method: Carbon dioxide in a supercritical state is used as an extractant. Supercritical carbon dioxide has good solvent properties and high diffusivity, can selectively extract artemisinin, and can avoid organic solvent residues, which is beneficial to improving the quality of the extract, but the equipment cost is relatively high.

Powder Texture Artemisinin has a Certain Solubility

Shaanxi Baisfu Bioengineering Co., Ltd. is an enterprise specializing in the research and development, production and sales of flavors and fragrances. The company is located in Building A, Baodeyun Valley, No. 52, Jinye 1st Road, Yanta District, Xi'an City, Shaanxi Province. It has an excellent geographical location and convenient transportation. convenient. The company was established in December 2019, with a registered capital of 3 million yuan.

Shaanxi Baisfu Bioengineering Co., Ltd，The company's main products include cooling agents, synthetic flavors and natural flavors. The company's products can be used in food and beverage, 

daily chemical, and other industries, and have a wide range of downstream applications.

The company always attaches great importance to product quality and brand reputation, strictly implements product quality and environmental management control, and has passed various certifications such as GPM, ISO9001, ISO14001, kosher, and HALAL European analysis.

The company's products are used by more than 30 foreign companies and regions. After more than ten years of technology accumulation and market development, the company has accumulated a group of high-quality customer groups, stable customer channels and resources, and has established relationships with more than 100 domestic and foreign companies. Good working relations.

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