High-Purity Camptothecin is Extracted from the Fruit, Root Bark, and Bark of Camptotheca Acuminata

Product Attribute

High-Purity Camptothecin is Extracted from the Fruit, Root Bark, and Bark of Camptotheca Acuminata

Source and extraction method：

Source: Camptotheca acuminata is a deciduous tree of the genus Camptotheca in the family Camptotheca genus, which can reach more than 20 meters in height. The bark is gray or light gray, and is longitudinally cracked into shallow grooves. The leaves are alternate, papery, oblong-ovate or oblong-elliptical, 12-28 cm long and 6-12 cm wide, with short sharp tips at the top, nearly rounded or broadly cuneate at the base, entire, bright green above, and light green below. The flowers are unisexual and monoecious, and most are arranged in spherical capitula, with female flowers terminal and male flowers axillary. The fruit is achene, narrow and oblong, with wings. Camptothecin is mainly extracted from the fruit, root bark, bark and other parts of Camptotheca acuminata.

Extraction method:

Organic solvent extraction method: This is a commonly used extraction method. Generally, organic solvents such as ethanol, methanol, and chloroform are used to soak and reflux the plant materials (such as fruits, bark, etc.) of Camptotheca acuminata. For example, after crushing the fruit of Camptotheca acuminata, soak it in ethanol solution and heat it under reflux to dissolve camptothecin in the solvent. After filtering, concentration and other operations, an extract containing camptothecin is obtained. Then, through column chromatography, recrystallization and other separation and purification techniques, camptothecin with higher purity is obtained.

Supercritical fluid extraction method: carbon dioxide in a supercritical state is used as an extractant. Supercritical carbon dioxide has good solvent properties and high diffusivity, can selectively extract camptothecin, and can avoid organic solvent residues, which is beneficial to improve the quality of the extract, but the equipment cost is relatively high.

High-Purity Camptothecin is Extracted from the Fruit, Root Bark, and Bark of Camptotheca Acuminata

Product Information

Camptothecin is a natural alkaloid extracted from Camptotheca acuminata, belonging to the quinoline alkaloids.

Chemical structure and properties

Chemical structure: The chemical structure of camptothecin is relatively complex. Its core is a five-ring structure containing a quinoline ring and an α-hydroxy-δ-lactone ring, with a molecular formula of . This unique lactone ring structure is the key part of camptothecin's anticancer activity. It can undergo reversible hydrolysis under physiological conditions, and this hydrolysis equilibrium has an important influence on its anticancer effect.

Physical properties: Camptothecin is usually a pale yellow needle-shaped crystal with a melting point between 264 and 267°C. It is almost insoluble in water, slightly soluble in organic solvents such as ethanol and chloroform, and easily soluble in alkaline organic solvents such as pyridine.

Chemical properties: The chemical properties of camptothecin are mainly related to its lactone ring. The lactone ring is easy to open the ring to form a carboxylate under alkaline conditions, and can be closed again under acidic conditions. This property may cause camptothecin to undergo structural changes under different physiological environments, thus affecting its biological activity. In addition, the nitrogen atom in the camptothecin molecule makes it alkaline to a certain extent, and it can react with acid to form salt.

High-Purity Camptothecin is Extracted from the Fruit, Root Bark, and Bark of Camptotheca Acuminata

Shaanxi Baisfu Bioengineering Co., Ltd. is an enterprise specializing in the research and development, production and sales of flavors and fragrances. The company is located in Building A, Baodeyun Valley, No. 52, Jinye 1st Road, Yanta District, Xi'an City, Shaanxi Province. It has an excellent geographical location and convenient transportation. convenient. The company was established in December 2019, with a registered capital of 3 million yuan.

Shaanxi Baisfu Bioengineering Co., Ltd，The company's main products include cooling agents, synthetic flavors and natural flavors. The company's products can be used in food and beverage, 

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