Notoginseng Folium P.E Regulates Signaling pathways in Nerve Cells

Product Attribute

Notoginseng Folium P.E Regulates Signaling pathways in Nerve Cells

Chemical structure and properties：

Chemical structure: Panax notoginseng total saponin is a mixture of multiple saponin components, the main components include ginsenoside Rb1, Rg1, Re, etc. The chemical structure of these saponin components is relatively complex, and they are glycosides formed by the combination of steroidal or triterpenoid compounds and sugars. Their molecular structure contains multiple sugar groups and sapogenins. The sapogenin part usually has the structure of tetracyclic triterpenes or pentacyclic triterpenes, and the sugar group part includes glucose, rhamnose, arabinose, etc.

Physical properties: Panax notoginseng total saponin is generally a pale yellow amorphous powder, bitter and slightly sweet. It has a certain solubility in water and better solubility in organic solvents such as methanol and ethanol. Its aqueous solution can produce persistent foam after shaking, which is one of the typical characteristics of saponin compounds.

Chemical properties: Panax notoginseng total saponin has certain chemical activity due to the presence of sugar groups and sapogenins in its molecular structure. It can react with some metal ions, such as lead ions and barium ions, to form precipitation. At the same time, the hydroxyl and other functional groups of its sapogenin part can participate in chemical reactions such as oxidation and esterification. These reaction characteristics provide a basis for its pharmacological effects and drug development.

Physiological function

Protective effect on the cardiovascular system:

Anti-myocardial ischemia: Panax notoginseng total saponins can dilate coronary arteries, increase coronary blood flow, and improve myocardial blood supply. In the myocardial ischemia model, it can reduce the damage of myocardial cells and reduce the area of myocardial infarction. Its mechanism of action may be related to regulating the energy metabolism of myocardial cells and inhibiting the apoptosis of myocardial cells.

Regulating blood pressure: It has a bidirectional regulating effect on blood pressure. For patients with hypertension, Panax notoginseng total saponins can lower blood pressure by dilating blood vessels and reducing peripheral resistance; for patients with hypotension, it can increase blood pressure by enhancing cardiac function and maintaining blood pressure within the normal range.

Anti-arrhythmic: It can inhibit the occurrence of arrhythmias. It can regulate ion channels on the myocardial cell membrane, such as potassium ion channels, calcium ion channels, etc., maintain the electrophysiological stability of myocardial cells, thereby reducing the occurrence of arrhythmias such as premature beats and tachycardia.

Hemostasis and blood circulation: Panax notoginseng saponins have unique dual effects of hemostasis and blood circulation. When bleeding, it can promote platelet aggregation and activation of coagulation factors, shorten coagulation time, and play a role in hemostasis. In normal physiological state or blood stasis state, it can inhibit excessive platelet aggregation, reduce blood viscosity, improve blood circulation, prevent thrombosis, and play a role in blood circulation.

Protective effect on cerebrovascular system:

Improve cerebral blood circulation: It can dilate cerebral blood vessels, increase cerebral blood flow, and improve blood supply to the brain. For ischemic cerebrovascular diseases, such as cerebral infarction and transient ischemic attack, Panax notoginseng saponins can reduce ischemic and hypoxic damage to brain tissue and promote the recovery of neurological function.

Neuroprotective effect: In the brain injury model, Panax notoginseng saponins can inhibit the apoptosis of nerve cells, reduce brain edema, and protect neurons. Its mechanism of action may involve regulating signal pathways in nerve cells, such as inhibiting oxidative stress response and reducing the expression of inflammatory factors.

Notoginseng Folium P.E Regulates Signaling pathways in Nerve Cells

Product Information

Panax notoginseng extract mainly refers to Panax notoginseng saponins (PNS), which is an effective ingredient extracted from Panax notoginseng, a traditional Chinese medicine, with multiple pharmacological effects and wide applications.

Source and extraction method

Source: Panax notoginseng is a perennial herb of the genus Panax in the Araliaceae family, mainly distributed in Yunnan, Guangxi and other places. Its plant height is 30-60 cm, with short rhizomes, upright stems, smooth and hairless. Palmate compound leaves, 3-4 pieces are whorled at the top of the stem, and the leaflets are usually 5-7 pieces, oblong or oblong-obovate, with fine serrations on the edges. Umbels are solitary at the top of the stem, with small, yellow-green flowers. The fruit is a drupe-like berry, nearly kidney-shaped, and red when ripe. Panax notoginseng saponins are mainly derived from the roots and rhizomes of Panax notoginseng.

Extraction method:

Organic solvent extraction: This is a more commonly used extraction method. Generally, organic solvents such as ethanol and methanol are used to soak, reflux extract or ultrasonic-assisted extract Panax notoginseng. First, the roots and rhizomes of Panax notoginseng are crushed, then soaked in an organic solvent, and the total saponins of Panax notoginseng are dissolved in the solvent by heat reflux or ultrasonic treatment. After extraction, the extract containing total saponins of Panax notoginseng is obtained by filtration, concentration and other operations. After that, column chromatography, high performance liquid chromatography and other methods can be used for further separation and purification to obtain total saponins of Panax notoginseng with higher purity.

Supercritical fluid extraction method: carbon dioxide in a supercritical state is used as an extractant. Supercritical carbon dioxide has good solvent properties and high diffusivity, can selectively extract total saponins of Panax notoginseng, and can avoid organic solvent residues, which is beneficial to improve the quality of the extract, but the equipment cost is relatively high.

Notoginseng Folium P.E Regulates Signaling pathways in Nerve Cells

Shaanxi Baisfu Bioengineering Co., Ltd. is an enterprise specializing in the research and development, production and sales of flavors and fragrances. The company is located in Building A, Baodeyun Valley, No. 52, Jinye 1st Road, Yanta District, Xi'an City, Shaanxi Province. It has an excellent geographical location and convenient transportation. convenient. The company was established in December 2019, with a registered capital of 3 million yuan.

Shaanxi Baisfu Bioengineering Co., Ltd，The company's main products include cooling agents, synthetic flavors and natural flavors. The company's products can be used in food and beverage, 

daily chemical, and other industries, and have a wide range of downstream applications.

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The company's products are used by more than 30 foreign companies and regions. After more than ten years of technology accumulation and market development, the company has accumulated a group of high-quality customer groups, stable customer channels and resources, and has established relationships with more than 100 domestic and foreign companies. Good working relations.

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